What Can Be Done For Pancreatic Cancer – This booklet for patients and caregivers describes pancreatic cancer, its causes and symptoms. It gives detailed information about the diagnostic tests used and the stages of pancreatic cancer. It includes a section on what to ask your doctor, where to go for more information and a glossary that will explain many of the terms used.
Pancreatic cancer can be a difficult condition to diagnose. The symptoms of the disease can be vague and therefore mistaken for other more common conditions.
What Can Be Done For Pancreatic Cancer
A misdiagnosis of pancreatic cancer can extend the time between the doctor’s visit and the correct diagnosis. Misdiagnosed patients also have, on average, more visits to their GP and more diagnostic tests.
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This increases the risk of pancreatic cancer being diagnosed late. To help your doctor correctly diagnose your condition, it may help to record how you feel and raise awareness of pancreatic cancer using our symptom diary.
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Prognosis Of Distal Pancreatic Cancers Controlled By Stage
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Pancreatic Cancer: Signs, Symptoms, And Complications
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive form of cancer with a dismal prognosis. The absence of symptoms in the early stage of the disease makes early diagnosis challenging, and approximately 80-85% of patients are diagnosed only after the disease progresses locally or metastasizes. The current front-line treatment landscape for local stages includes surgical resection and adjuvant chemotherapy. In Switzerland, although both FOLFIRINOX and gemcitabine plus nab-paclitaxel regimens are feasible and comparable in first-line, FOLFIRINOX is preferred in the respective treatment (Eastern Cooperative Oncology Group [ECOG] performance status [PS]: 0-1), young patients (65 years) with Few comorbidities and normal liver function, while gemcitabine plus nab-paclitaxel is used to treat less fit (ECOG PS: 1-2) and more vulnerable patients. In the second-line setting of advanced PDAC, there is currently only one approved regimen, based on the Phase III NAPOLI-1 trial. Furthermore, the use of liposomal-irinotecan in second-line is supported by real-world data. Beyond the therapeutic standard, various alternative treatment methods are tested in clinical studies. Immunotherapy has so far demonstrated only limited benefits, and only in cases of high microsatellite instability (MSI-H). However, data on the utility of poly (ADP-ribose) polymerase (PARP) inhibition as maintenance therapy in patients with BRCA -mutated tumors may signal progress in targeted therapy. Currently, there is a lack of molecular and genetic biomarkers for optimal stratification of patients and for guiding treatment decisions. Therefore, the identification of predictive and prognostic biomarkers and the evaluation of new treatment strategies are equally relevant to improve the prognosis of metastatic pancreatic cancer patients. Pancreatic cancer has the best treatment outcomes when it is diagnosed in the early stages. But early pancreatic cancer is usually asymptomatic, and the first warning signs of pancreatic cancer often overlap with other, less serious conditions.
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